Tuberculosis Drug Therapy | Side effects of all tb drugs | Medi tutorials

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by, Fojla Rahman Zia

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Adverse effect of Anti Tubercular Drug:

Isoniazide:

*Peripheral neuropathy in slow acetylator

(Burning sensation of feet, numbness, tingling)

*Hepatotoxicity in rapid acetylator

*CNS toxicity :Restlessness,Insomnia, psychosis

*GIT discomfort.

adverse effects Rifampicine:

*Harmless orange or red coloration of urine,tear,

saliva, cvontact lens.

*Liver damage- hepatitis, cholestatic jaundice

*Rashes,nephritis,thrombocytopenia

*Flue like syndrome.

adverse effects Pyrazinamide:

*Acute gouty arthritis

*hyperuricaemia

*hepatotoxicity

*nausea, vomitting.

adverse effects Ethambutol:

*Retrovalvar neuritis

*Arthralgia

*GIT disturbance

*headache, giddiness.

One adverse effect must be memorise:

isoniazide- peripheral neuropathy.

rifampicin- harmless orange or red colour of urine, tear, saliva.

pyrazinamide- acute gouty arthritis

ethambutol-retrovalvar neuritis.

For pervention of peripheral neuropathy in slow acetylator pyridoxine along with isoniazide is given to the patient ... 

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 Pharmacology