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Insulin preparation
Insulin is a small protein containg two polypeptide chain connected by disulfide bonds.
key points:
*Insulin can be exists as- monomer, dimer, hexamer.
*It is stored in the granules of pancreatic B-cell.
*Monomer is the biological active form of insulin.
*Molecular weight of insulin is 5808.
Now Insulin Preparation :
*Rapid acting insulin.
*Short acting insulin.
*Intermediate acting insulin.
*Pre-mixed insulin.
*Long acting insulin.
*Rapid acting insulin:
Insulin lispro
Insulin Aspart
Insulin Glulisine.
*Short acting insulin:
Regular Novolin R
Regular Humulin R
Velosulin
Regular Exubera.
*Intermediate acting insulin:
NPH Humulin N
NPH Novolin N.
*Pre-mixed insulin:
Novolin 70/30
Humulin 70/30
50/50 NPL
75/25 NPL
70/30 NPA
(here NPL=neutral protamine lispro.
NPA=neutral protamine aspart.)
*Long acting insulin:
Insulin determir
Insulin glargine.
Pre-mixed insulin is produced by combination of regular, intermediate, short acting insulin, that's why it is given to the patients at 1 dose within 24 hours!
That's All....
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Hellow i am Fojla Rahman Zia. Now I am Studying 5th Year MBBS at Dhaka Community Medical College. 