Drug therapy of Migrane | Migrane Prophylaxis | Medi Tutorials

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Written by, Fojla Rahman Zia

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Drug therapy of Migrane:

Migrane is more common in female than male.
Migrane is also associated with extracranial vasodilatation.


Acute attack-----
       mild case:
paracetamol/ NASIDs or their combination
(+-) anti emetics
       moderate case:
NASIDs or combination/ Triptans/ Ergot alkaloids
(+) anti emetics
       severe case:
Triptans/ Ergot alkaloids
(+)anti emetics
(+)prophylaxis

Antiemetics:
metoclopramide
domperidone
promethazine
diphenhydramine

NASIDs combination:
ibuprofen
naproxen
diclofene
indomethacin

Triptans:
sumatriptan
rizatriptan

Ergot alkaloids:
ergotamine tartrate

Prophylaxis of Migrane:
Propranolol
Pizotifen
Na-Valproate
Amitriptyline.

Why triptans are used for migrane therapy?
Triptan causes increase seratonin level in blood vessels .We know  seratonin is a mediator of vosoconstriction which causes extracranial vasoconstriction and reduce migrane pain.

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 Pharmacology